Nuplura PH + 5

RIGHT WHEN IT MATTERS
NUPLURA PH+ delivers the right protection at the right time. Vaccinate animals for just what they need right when it matters. NUPLURA PH+ delivers protection against M. haemolytica and viral causes of BRD in one vaccination so it is less stressful on the animal and requires less labor and time to administer.

FAST-ACTING IMMUNITY
Immunity with NUPLURA PH+ has fast onset of immunity against M. haemolytica—just 10 days. It has also been demonstrated to be safe for calves as young as 28 days.

EASY ON CATTLE
NUPLURA PH+ uses only purified antigens allowing for a smooth vaccination while still providing a strong immune response.1 NUPLURA PH+ combines smooth with power for a difference you can see such as minimal swelling at injection sites.

POWERFUL PROTECTION
The combination in NUPLURA PH+5 provides powerful protection against both bacterial and viral pathogens that cause BRD and weakened immune systems in one shot. NUPLURA PH+5 uses advanced recombinant technology—a process that focuses the immune response on building immunity with minimal adverse side effects.

TECHNICAL DISEASE INFORMATION
MANNHEIMIA HAEMOLYTICA
Mannheimia haemolytica is the primary bacterial species involved with bovine respiratory disease which is estimated to cost North American feedlots US $1 billion annually.4 M. haemolytica is connected to serious outbreaks of acute pneumonia in neonatal, weaned and growing calves, and pneumonia in adult cattle. Transportation, viral infections such as BVD or IBR, overcrowding, weaning and other stressful conditions predispose animals to M. haemolytica. Animals with M. haemolytica can experience: • Lack of appetite • Increased nasal discharge • Fever • Labored breathing • Cough

PARAINFLUENZA-3 (PI3)
• Endemic infection in cattle populations • Usually mild, consisting of fever, nasal discharge, and dry cough • Part of the BRD complex of viruses

BOVINE VIRAL DIARRHEA (BVD)
BVD virus is one of the most prevalent and challenging bovine pathogens in the world. There are hundreds of BVD viral strains, and the number continues to increase due to the mutating nature of the virus. The BVD virus manifests itself in numerous ways, including: • Bovine respiratory disease • Hemorrhagic (bleeding) syndrome • Reproductive disorders, including infertility, abortion and neonatal defects • Persistently infected (PI) calves that shed infective virus throughout their lives • Gastrointestinal disorders • Mucosal disease in PI calves

INFECTIOUS BOVINE RHINOTRACHEITIS (IBR)
IBR, sometimes referred to as “red nose,” is caused by bovine herpesvirus-1. The IBR virus is associated with: • Upper respiratory tract infections • Bovine respiratory disease • Eye disorders like conjunctivitis Reproductive disorders such as infectious pustular vulvovaginitis, abortion and neonatal death

BOVINE RESPIRATORY SYNCYTIAL VIRUS (BRSV)
• Predominantly in young beef and dairy cattle less than 6 months old • Considered a primary bovine respiratory disease (BRD) pathogen and is also a component of the BRD complex • Clinical signs: • Fever (40–42ºC [104–108ºF) • Decreased feed intake • Increased respiratory rate • Cough • Nasal and lacrimal discharge